RecentRCT

VentSetFib

Ventilator settings for fiberoptic bronchoscopy during mechanical ventilation: a randomized adjudicator-blinded controlled trial VentSetFib

Critical Care, 2026 · Single-center randomized adjudicator-blinded trial, 46 patients

Population: Intubated adults undergoing flexible bronchoscopy
Intervention: Bronchoscopy-specific lower inspiratory flow and tidal volume strategy
Comparator: Conventional ventilation settings
Primary outcome: Composite events requiring premature bronchoscopy interruption
Result: The composite occurred in 1/23 versus 22/23, largely from pressure-alarm-limited ventilation; oxygenation and circulatory events were uncommon.

What the trial found

The composite occurred in 1/23 versus 22/23, largely from pressure-alarm-limited ventilation; oxygenation and circulatory events were uncommon.

Current guideline position

This trial must be interpreted alongside indication-specific guidance; its result alone does not establish a universal treatment policy.

Clinical interpretation

Assess delivered ventilation, expiratory time and tube/scope compatibility. Do not copy the experimental alarm limits into a universal bedside protocol.

Limitations

Small single-center study with device-specific conditions.
The endpoint mostly reflected ventilation delivery, not mortality or severe hypoxemia.

Clinical Context & Relevant Topics (2)

Disease Reference

Bronchoscopy in the ICU

Safe diagnostic and therapeutic bronchoscopy in hypoxemic, mechanically ventilated and bleeding ICU patients

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Invasive Mechanical Ventilation

Complete clinical topic overview. For the full 10-level interactive course, visit Master MV. Covers core ventilator modes, respiratory mechanics (Cstat, Raw, driving pressure), waveform dyssynchrony analysis, VILI prevention, and liberation protocols.

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