GuidelineCurrent
SSC 2026 — Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026
Society of Critical Care Medicine / European Society of Intensive Care Medicine, 2026
Suggest against sodium bicarbonate to improve hemodynamics or reduce vasopressor requirements in lactic acidemia generally, but suggest sodium bicarbonate in severe metabolic acidemia (pH ≤ 7.2) with concurrent acute kidney injury (AKIN stage 2-3).
Conditional recommendationVery low certainty
View source guidelineClinical Context & Relevant Topics (2)
Disease ReferenceSeptic Shock
The subset of sepsis with profound circulatory and cellular/metabolic abnormality — clinically identified by a vasopressor requirement to maintain MAP ≥ 65 mmHg plus lactate > 2 mmol/L despite adequate fluid resuscitation.
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Acute Kidney Injury in Critical Care
Sepsis-AKI microcirculatory decoupling, KDIGO staging, Furosemide Stress Test (FST), urine microscopy, and the AEIOU dialysis threshold framework.
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