Advanced assisted ventilation modes for weaning from invasive mechanical ventilation in adult patients: a systematic review and network meta-analysis of randomized controlled trials
Sella N et al., 2026 · 23 studies included
Summary
23 RCTs, 3,755 adults; search to March 2026, early accepted October publication. Sparse network and predominantly indirect advanced-mode comparisons.
Conclusion
NAVA weaning-success evidence was low certainty; hospital-mortality and asynchrony signals require confirmation. No clear ICU/28-day mortality or reintubation advantage. Early abstract/body estimates differ; avoid unqualified numeric superiority or a universal mode ranking.