Implementation of a kidney protection strategy to prevent acute kidney injury after major surgery in high-risk patients identified by biomarkers: a systematic review and individual participant data meta-analysis of randomized controlled trials
von Groote T et al., 2026 · 4 studies included
Summary
Individual participant data from four randomized trials, 1,851 biomarker-enriched high-risk major-surgery patients.
Conclusion
A kidney-protection bundle reduced stage ≥2 AKI within 72 hours (17.7% versus 27.1%; OR 0.55, 95% CI 0.44–0.70). The incremental value of biomarker selection itself and broader patient-centered benefits remain uncertain.