Intravenous Immunoglobulin for Guillain-Barré Syndrome
Hughes RA, et al. (Cochrane Neuromuscular Group), 2014 · 12 studies included
Summary
Cochrane systematic review and meta-analysis of 12 randomized trials involving 1,171 participants comparing IVIG with plasma exchange or supportive care in moderate to severe Guillain-Barré syndrome.
Conclusion
IVIG started within two weeks of onset hastens recovery as effectively as plasma exchange, with no significant difference in disability improvement, mortality, or time to ventilator liberation, while demonstrating greater treatment completion and fewer adverse events.
Clinical Context & Relevant Topics (2)
Disease ReferenceCritical illness polyneuropathy and myopathy: recognition, risk reduction, diagnostic approach, ventilator liberation, rehabilitation, and prognosis.
Complete clinical topic overview. For the full 10-level interactive course, visit Master MV. Covers core ventilator modes, respiratory mechanics (Cstat, Raw, driving pressure), waveform dyssynchrony analysis, VILI prevention, and liberation protocols.