Intensive Care Outcomes for Patients with Cancer: A Systematic Review and Meta-Analysis
Puxty K, et al., 2014 · 42 studies included
Summary
Systematic review and meta-analysis of 42 studies comprising 122,860 critically ill cancer patients admitted to modern intensive care units.
Conclusion
Overall hospital mortality for cancer patients admitted to the ICU was 44%, with significant progressive decadal survival improvements. Prognosis is predominantly determined by the number and severity of acute physiological organ dysfunctions and mechanical ventilation requirement rather than cancer type or stage per se.
Clinical Context & Relevant Topics (3)
Disease ReferenceHost immune defects, neutropenic sepsis, acute respiratory failure (PJP/Aspergillus), tumor lysis syndrome, leukostasis, CAR-T CRS/ICANS, and ICU triage.
Life-threatening organ dysfunction caused by a dysregulated host response to infection — recognized by an acute rise in SOFA score, not by infection plus fever alone.
Acute, diffuse inflammatory lung injury causing hypoxemia and bilateral infiltrates not fully explained by cardiac failure or fluid overload.