LandmarkRCT

UK-REBOA

Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial.

JAMA, 2023 · Pragmatic randomized Bayesian trial

Population: 90 randomized trauma patients; 89 with primary data
Intervention: REBOA plus standard care
Comparator: Standard care
Primary outcome: 90-day all-cause mortality
Result: 54% versus 42%; Bayesian OR 1.58 (95% credible interval 0.72–3.52), 86.9% probability of increased odds of death.

What the trial found

54% versus 42%; Bayesian OR 1.58 (95% credible interval 0.72–3.52), 86.9% probability of increased odds of death.

Clinical interpretation

No demonstrated survival benefit, concerning harm signal and imprecision. Expert rescue selection must not delay definitive hemorrhage control.

Moderate certainty

Clinical Context & Relevant Topics (1)

Disease Reference

Polytrauma & Damage-Control Critical Care

ICU priorities after major multisystem trauma: hemorrhage control, damage-control resuscitation, TBI-aware perfusion, coagulopathy correction, compartment syndromes and staged definitive care.

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