RecentRCT

Internet CBT after MINOCA/Takotsubo

Randomized Controlled Trial of Internet-Delivered Cognitive Behavioral Therapy After Myocardial Infarction With Nonobstructive Coronary Arteries or Takotsubo Syndrome.

Journal of the American Heart Association, 2026 · Multicenter randomized trial

Population: 88 adults with elevated stress/anxiety and mixed diagnoses
Intervention: Tailored internet CBT
Comparator: Wait-list
Primary outcome: Normalized stress/anxiety at 10–12 weeks
Result: Primary OR 2.37 (95% CI 0.88–6.38), P=.09; some secondary measures improved.

What the trial found

Primary OR 2.37 (95% CI 0.88–6.38), P=.09; some secondary measures improved.

Clinical interpretation

Primary endpoint not met; subgroup and secondary findings exploratory, not acute cardiac treatment.

Moderate certainty

Clinical Context & Relevant Topics (1)

Disease Reference

Takotsubo Syndrome (Stress Cardiomyopathy)

Transient stress-associated ventricular dysfunction that can mimic ACS and cause pulmonary edema, arrhythmia, LVOTO, thrombus, or cardiogenic shock.

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