LandmarkRCT

TEAM

Early Active Mobilization during Mechanical Ventilation in the ICU.

The New England journal of medicine, 2022 · Multicenter randomized trial

Population: 750 mechanically ventilated ICU adults
Intervention: Increased early active mobilization
Comparator: Usual mobilization
Primary outcome: Days alive outside hospital to day 180
Result: 143 versus 145 median days; no significant benefit. Potentially mobilization-related adverse events 9.2% versus 4.1%.

What the trial found

143 versus 145 median days; no significant benefit. Potentially mobilization-related adverse events 9.2% versus 4.1%.

Clinical interpretation

Do not force higher exercise dose regardless of safety; neutral trial does not justify unnecessary immobility.

Moderate certainty

Clinical Context & Relevant Topics (1)

Disease Reference

Post-ICU Syndrome, Survivorship & Rehabilitation

Prevention, recognition and follow-up of physical, cognitive and psychological morbidity after critical illness, including ICU-acquired weakness and family impact.

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