RecentRCT

iRehab

Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors: A Randomized Clinical Trial.

JAMA, 2026 · Multicenter randomized trial

Population: 429 UK ICU survivors, ventilated ≥48 h, within 12 weeks of discharge
Intervention: Six-week remote personalized multicomponent rehabilitation
Comparator: Standard care
Primary outcome: Eight-week EQ-5D-5L utility
Result: No significant primary benefit; adjusted mean difference 0.04 (95% CI −0.001 to 0.09). Selected secondary function/fatigue/anxiety measures improved.

What the trial found

No significant primary benefit; adjusted mean difference 0.04 (95% CI −0.001 to 0.09). Selected secondary function/fatigue/anxiety measures improved.

Clinical interpretation

Postdischarge selected participants; secondary benefits are not proof of primary quality-of-life or survival improvement.

Moderate certainty

Clinical Context & Relevant Topics (1)

Disease Reference

Post-ICU Syndrome, Survivorship & Rehabilitation

Prevention, recognition and follow-up of physical, cognitive and psychological morbidity after critical illness, including ICU-acquired weakness and family impact.

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