LandmarkRCT

TEAM

Primary publication linked by DOI, 2022 · Randomized trial

Population: 750 invasively ventilated adults
Intervention: Increased early active mobilization
Comparator: Usual care
Primary outcome: Days alive out of hospital at day 180
Result: 143 versus 145 days; difference −2 (95% CI −10 to 6), P=.62; potentially related adverse events 9.2% versus 4.1%.

What the trial found

143 versus 145 days; difference −2 (95% CI −10 to 6), P=.62; potentially related adverse events 9.2% versus 4.1%.

Clinical interpretation

More intensity did not improve the primary outcome and increased adverse events; individualize safe rehabilitation.

Moderate certainty

Clinical Context & Relevant Topics (1)

Disease Reference

Critical illness polyneuropathy and myopathy: recognition, risk reduction, diagnostic approach, ventilator liberation, rehabilitation, and prognosis.