LandmarkRCT

PRONECMO

Prone Positioning During Extracorporeal Membrane Oxygenation in Patients With Severe ARDS: The PRONECMO Randomized Clinical Trial.

JAMA, 2023 · Multicenter randomized trial

Population: 170 VV-ECMO patients, mainly COVID and previously proned
Intervention: At least four 16-hour prone sessions
Comparator: Supine
Primary outcome: Successful ECMO weaning by day 60
Result: 44% versus 44%; no significant 90-day mortality benefit.

What the trial found

44% versus 44%; no significant 90-day mortality benefit.

Clinical interpretation

Neutral selected on-ECMO study; does not negate pre-ECMO proning or prove equivalence in all populations.

Moderate certainty

Clinical Context & Relevant Topics (1)

Disease Reference

ECMO: Physiology, Bedside Management & Troubleshooting

Specialist-level VV/VA ECMO bedside management: selection, cannulation, gas exchange, hemodynamics, anticoagulation, circuit troubleshooting, organ support, ultrasound, ECPR, weaning and decannulation.

View Topic Context →