LandmarkRCT

Donor hypothermia versus kidney machine perfusion

Hypothermia or Machine Perfusion in Kidney Donors.

The New England journal of medicine, 2023 · Multicenter randomized trial

Population: 725 donors; 1,349 transplanted kidneys
Intervention: Donor hypothermia or combination
Comparator: Ex-situ hypothermic machine perfusion
Primary outcome: Delayed graft function requiring dialysis within seven days
Result: DGF 30% hypothermia, 19% perfusion, 22% combination; hypothermia inferior and combination had no clear added protection.

What the trial found

DGF 30% hypothermia, 19% perfusion, 22% combination; hypothermia inferior and combination had no clear added protection.

Clinical interpretation

Kidney-specific preservation comparison, not a universal heart/lung donor temperature rule. One-year graft survival similar.

Moderate certainty

Clinical Context & Relevant Topics (1)

Disease Reference

Organ Donation & Donor Management

Ethically separated death determination, timely organ-procurement referral, and physiology-focused donor support after BD/DNC or planned donation after circulatory death.

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