RecentRCT

COBRA — DDW 2026 abstract

One day versus 4–7 days after adequate biliary drainage: COBRA conference report

DDW 2026 conference abstract, 2026 · Open-label multicenter noninferiority trial; conference report, full results publication not verified

Population: 413 randomized adults after adequate distal drainage and fever resolution; excluded immunosuppression/concomitant infection
Intervention: One day of antibiotics
Comparator: 4–7 days
Primary outcome: Clinical cure
Result: 95.1% versus 93.7%; difference 1.5%, one-sided 95% lower limit −2.4%, margin −7.5%.

What the trial found

Conference abstract reported noninferiority in intention-to-treat and per-protocol analyses.

Clinical interpretation

Preliminary and selected population; not a universal duration for ongoing shock or incomplete control.

Limitations

Conference-level report; protocol DOI 10.1186/s13063-026-09524-7 is not the results publication.

Low certainty

Clinical Context & Relevant Topics (1)

Disease Reference

Recognition, antibiotics, resuscitation and urgent biliary source control for severe cholangitis and septic shock