RecentRCT

ABRUPT2

A Prospective, Randomized, Multicenter Trial Comparing Lactated Ringer's Alone or With 5% Albumin for Resuscitation of Large Burns The Acute Burn ResUscitation Multicenter Prospective Trial 2 (ABRUPT2).

Annals of surgery, 2026 · Multicenter randomized trial

Population: 99 adults with large/deep burns; stopped for enrollment difficulty
Intervention: LR plus 5% albumin
Comparator: LR alone
Primary outcome: Fluid requirement over first 48 hours
Result: Lower 24/48-hour fluid volumes with albumin; 51% LR-to-albumin crossover. Mortality, healing and AKI did not significantly differ.

What the trial found

Lower 24/48-hour fluid volumes with albumin; 51% LR-to-albumin crossover. Mortality, healing and AKI did not significantly differ.

Clinical interpretation

Fluid-volume benefit, not established survival benefit or one universal dose/timing. Early stop and crossover constrain precision.

Moderate certainty

Clinical Context & Relevant Topics (1)

Disease Reference

Burns & Major Burn Critical Care

Inhalation injury management, endpoint-driven fluid resuscitation, avoidance of fluid creep, bedside escharotomy, and hypermetabolic catabolism support.

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