RecentRCT

DAPA ACT HF decongestion analysis

Effect of In-Hospital Initiation of Dapagliflozin on Decongestion in Patients Hospitalized for Heart Failure: An Analysis of the DAPA ACT HF-TIMI 68 Trial.

JACC. Heart failure, 2026 · Prespecified secondary analysis of a randomized trial

Population: Participants from the parent DAPA ACT HF-TIMI 68 trial
Intervention: Dapagliflozin
Comparator: Placebo
Primary outcome: Congestion/weight/loop-dose measures over two months
Result: Modest congestion and weight improvement by one week; no new independent mortality comparison.

What the trial found

Modest congestion and weight improvement by one week; no new independent mortality comparison.

Clinical interpretation

Reuses parent participants; not a second confirmatory outcome trial.

Low certainty

Clinical Context & Relevant Topics (2)

Disease Reference

Acute Heart Failure & Cardiogenic Congestion

Hemodynamic phenotypes (SCAPE vs ADHF vs Cardiogenic Shock), non-invasive positive pressure ventilation, high-dose vasodilator algorithms, loop diuretics, and sequential nephron blockade.

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Acute Cardiogenic Pulmonary Edema & SCAPE

Hydrostatic pulmonary edema physiology, SCAPE vs decompensated HF vs cardiogenic shock, NIV, titrated vasodilators when hypertensive, diuresis, and sequential nephron blockade.

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