ISTH 2020 — ISTH Guidelines for Treatment of Thrombotic Thrombocytopenic Purpura

This guideline has been superseded by a newer recommendation. Check the Knowledge Map or the current topic page for the guideline that replaces it.

Suspected immune TTP is a hematologic emergency: obtain ADAMTS13 testing before plasma therapy when feasible without delaying treatment, and initiate plasma exchange plus corticosteroids; caplacizumab and rituximab are incorporated according to the immune TTP pathway.