AABB/ICTMG Platelets 2025 — Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines

Use restrictive, indication-specific platelet thresholds. Examples include <10,000/uL for prophylaxis in nonbleeding hypoproliferative thrombocytopenia and compressible-site central venous catheter placement, <20,000/uL for lumbar puncture, and <50,000/uL for major non-neuraxial surgery. Avoid routine platelet transfusion for nonoperative intracranial hemorrhage when platelet count is >100,000/uL, including antiplatelet-associated ICH.