ConsensusCurrent

ACMT — Duration of intravenous acetylcysteine therapy following acetaminophen overdose: 2026 update

ACMT, 2026

Before stopping IV NAC require APAP <10 micrograms/mL, baseline or improving aminotransferases, INR <2 and improving prognostic markers. Persistent drug, hepatic injury or poor prognosis warrants continued treatment and expert review.

Expert opinionLow certainty

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Clinical Context & Relevant Topics (1)

Disease Reference

Toxicologic Emergencies in Critical Care

Resuscitate first, identify toxidromes and ECG/acid-base threats, use toxin-specific antidotes, and escalate early to poison-center, extracorporeal, or ECLS support when physiology demands it.

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