NCS TBI Seizure Prophylaxis 2024 — Guidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate-Severe Traumatic Brain Injury

In adults hospitalized with moderate-severe TBI and no prior clinical/electrographic seizure, either prophylactic ASM or no prophylaxis may be used (weak, low-quality evidence). If an ASM is used, levetiracetam is suggested over phenytoin/fosphenytoin (weak, very-low-quality evidence), for a short duration of no more than 7 days (weak, low-quality evidence).