GuidelineCurrent

SSC 2026 — Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026

Society of Critical Care Medicine / European Society of Intensive Care Medicine, 2026

Recommend an initial mean arterial pressure target of 65 mmHg in adults with septic shock requiring vasopressors, rather than a higher target, recognizing that exactly maintaining 65 mmHg is impractical and a reasonable range (roughly ±5 mmHg) is appropriate in practice.

Strong recommendationModerate certainty

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Clinical Context & Relevant Topics (1)

Disease Reference

Septic Shock

The subset of sepsis with profound circulatory and cellular/metabolic abnormality — clinically identified by a vasopressor requirement to maintain MAP ≥ 65 mmHg plus lactate > 2 mmol/L despite adequate fluid resuscitation.

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