SSC 2026 — Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026
Society of Critical Care Medicine / European Society of Intensive Care Medicine, 2026
Suggest early source control, within 6 hours of diagnosis, over delayed intervention when an anatomic source amenable to control is identified.
Clinical Context & Relevant Topics (4)
Disease ReferenceLife-threatening organ dysfunction caused by a dysregulated host response to infection — recognized by an acute rise in SOFA score, not by infection plus fever alone.
The subset of sepsis with profound circulatory and cellular/metabolic abnormality — clinically identified by a vasopressor requirement to maintain MAP ≥ 65 mmHg plus lactate > 2 mmol/L despite adequate fluid resuscitation.
ICU approach to perforation, abscess, postoperative leak, ischemic bowel and complicated intra-abdominal infection
Recognition, antibiotics, resuscitation and urgent biliary source control for severe cholangitis and septic shock