SCCM PADIS 2018 — Clinical Practice Guidelines for Prevention and Management of Pain, Agitation, Delirium, Immobility, and Sleep Disruption

Analgesia-first approach using validated pain scores (CPOT/BPS). Target light sedation (RASS -1 to 0) over deep sedation. Non-benzodiazepine sedatives (propofol or dexmedetomidine) are strongly preferred over benzodiazepine infusions to reduce ventilation time and delirium. Routine delirium screening (CAM-ICU/ICDSC). Implement the multi-component ABCDEF bundle (Assess/treat pain, Both SAT and SBT, Choice of sedation, Delirium monitoring/management, Early mobility, Family engagement). Do not use antipsychotics routinely to treat delirium.