SCCM PADIS 2025 — Focused Update to PADIS Guidelines for Adult ICU Patients
Society of Critical Care Medicine, 2025
The 2025 focused update conditionally suggests dexmedetomidine over propofol when light sedation and/or reduction in delirium are highest priorities, enhanced mobilization/rehabilitation over usual mobility care, and melatonin over no melatonin. Evidence was insufficient to recommend for or against antipsychotics over usual care for delirium treatment or benzodiazepines for ICU anxiety. Apply these recommendations with the patient’s clinical status and the broader 2018 PADIS framework.
Clinical Context & Relevant Topics (2)
Disease ReferenceSafe ICU use of antipsychotics: delirium evidence, agitation control, QTc/torsades risk, NMS, EPS, interactions, and deprescribing.
Analgesia-first sedation, light sedation targets, ABCDEF bundle, spontaneous breathing trials, and non-pharmacologic delirium mitigation.