ConsensusCurrent
HiHASC 2024 — Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults
HiHASC, 2024
Suspect adult HLH in an unexpectedly unwell patient with the practical pattern of fever, falling blood counts and raised ferritin; use structured assessment and trigger investigation because no single ferritin threshold or marrow finding is diagnostic.
Expert opinionLow certainty
View source guidelineClinical Context & Relevant Topics (2)
Disease ReferenceHLH / Macrophage Activation Syndrome
Adult ICU recognition, trigger investigation and individualized treatment of hemophagocytic lymphohistiocytosis/macrophage activation syndrome.
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Immunocompromised & Oncologic Critical Illness
Host immune defects, neutropenic sepsis, acute respiratory failure (PJP/Aspergillus), tumor lysis syndrome, leukostasis, CAR-T CRS/ICANS, and ICU triage.
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