GuidelineCurrent
ASCO/IDSA 2018 — Management of Fever and Neutropenia in Adults Treated for Malignancy: ASCO and IDSA Clinical Practice Guideline Update
ASCO / IDSA, 2018
Empiric broad-spectrum antipseudomonal beta-lactam monotherapy (cefepime, piperacillin-tazobactam, or meropenem) must be initiated within 1 hour of triage in febrile neutropenic patients. Vancomycin is not routinely recommended unless hemodynamic instability, catheter infection, pneumonia, or severe mucositis is present.
Strong recommendationHigh certainty
View source guidelineClinical Context & Relevant Topics (2)
Disease ReferenceFebrile Neutropenia & Neutropenic Sepsis
Time-critical ICU management of fever and organ dysfunction during neutropenia, with early antipseudomonal therapy and source-directed escalation.
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Immunocompromised & Oncologic Critical Illness
Host immune defects, neutropenic sepsis, acute respiratory failure (PJP/Aspergillus), tumor lysis syndrome, leukostasis, CAR-T CRS/ICANS, and ICU triage.
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