GuidelineCurrent

EAN/ESCMID — EAN ESCMID 2026 infectious encephalitis in adults

EAN/ESCMID, 2026

Start IV aciclovir promptly when infectious encephalitis is suspected. Do not replace pathogen-specific CSF PCR with multiplex PCR panels. Evidence is insufficient to recommend for or against adjunctive corticosteroids in proven HSV encephalitis; bacterial meningitis steroid recommendations are a separate indication.

Strong recommendationLow certainty

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Clinical Context & Relevant Topics (1)

Disease Reference

Acute Meningitis & Encephalitis

CT-before-LP criteria, CSF interpretation matrix, de Gans Dexamethasone timing, empiric age/host antimicrobial coverage + Ampicillin + Acyclovir, and neurocritical ICP management.

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