GuidelineCurrent
GOLD 2026 — Global Strategy for Prevention, Diagnosis and Management of COPD: 2026 Report
Global Initiative for Chronic Obstructive Lung Disease, 2026
Current GOLD strategy for COPD, including controlled oxygen in exacerbations, short-acting bronchodilators, short systemic corticosteroid courses for significant exacerbations, selective antibiotics, and NIV as preferred ventilatory support for acute hypercapnic respiratory failure with acidosis when appropriate.
Conditional recommendationModerate certainty
View source guidelineClinical Context & Relevant Topics (2)
Disease ReferenceCOPD Exacerbation (Acute & Severe)
Pathophysiology of acute-on-chronic hypercapnia, controlled oxygen targets (88–92%), evidence-based NIV, and auto-PEEP matching mechanics.
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Hypercapnic Respiratory Failure
Mechanism-based diagnosis of acute and acute-on-chronic hypercapnia, controlled oxygen, NIV, invasive ventilation, auto-PEEP troubleshooting, neuromuscular monitoring, and post-acute planning.
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