ConsensusCurrent

AASLD ALF Update — AASLD Position Paper: The Management of Acute Liver Failure — Update 2011

American Association for the Study of Liver Diseases, 2012

Suspected acute liver failure warrants early referral/transfer to a liver-transplant center. N-acetylcysteine is standard for acetaminophen-associated ALF; evidence for non-acetaminophen ALF is strongest for transplant-free survival in selected early encephalopathy. Prognostic tools such as King's College Criteria support, but do not replace, serial transplant-team assessment.

Expert opinionModerate certainty

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Clinical Context & Relevant Topics (1)

Disease Reference

Acute Liver Failure (ALF)

Hyperammonemia, cytotoxic cerebral edema, balanced coagulopathy, N-acetylcysteine, 3% saline neuroprotection, CRRT ammonia clearance, and King's College transplant criteria.

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