GuidelineCurrent

AHA/ASA AIS 2026 — 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke

American Heart Association / American Stroke Association, 2026

Updates prehospital triage and acute reperfusion care, expands tenecteplase use within 4.5 hours, broadens endovascular thrombectomy eligibility including selected large-core and posterior-circulation stroke populations, and updates supportive early management.

Conditional recommendationModerate certainty

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Clinical Context & Relevant Topics (1)

Disease Reference

Acute Ischemic Stroke

Core vs penumbra dynamics, ASPECTS & CT perfusion, Tenecteplase/Alteplase thrombolysis, DAWN/DEFUSE 3 extended thrombectomy, BP targets, and malignant MCA hemicraniectomy.

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