GuidelineCurrent
AHA Poisoning 2023 — Focused Update on Management of Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning
American Heart Association, 2023
Life-threatening sodium-channel blocker cardiotoxicity, including TCA poisoning, should be treated with sodium bicarbonate; refractory cardiogenic shock may require advanced rescue strategies including VA-ECMO in selected cases.
Conditional recommendationModerate certainty
View source guidelineClinical Context & Relevant Topics (2)
Disease ReferenceTricyclic & Sodium-Channel Blocker Toxicity
Recognition and resuscitation of sodium-channel blocker poisoning with seizures, QRS widening, ventricular dysrhythmia and shock.
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Toxicologic Emergencies in Critical Care
Resuscitate first, identify toxidromes and ECG/acid-base threats, use toxin-specific antidotes, and escalate early to poison-center, extracorporeal, or ECLS support when physiology demands it.
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