GuidelineCurrent

ACC/AHA ACS 2025 — 2025 Guideline for the Management of Patients With Acute Coronary Syndromes

ACC/AHA/ACEP/NAEMSP/SCAI, 2025

Current multisociety guidance for STEMI/NSTE-ACS, including antithrombotic therapy, invasive strategy, cardiogenic shock, and revascularization; in ACS with cardiogenic shock, emergency culprit-vessel revascularization is indicated while routine immediate nonculprit PCI is avoided.

Conditional recommendationModerate certainty

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Clinical Context & Relevant Topics (2)

Disease Reference

Acute Coronary Syndrome

Plaque rupture, coronary thrombosis, STEMI vs NSTEMI risk stratification, emergent reperfusion, DAPT/anticoagulation, and mechanical/electrical ICU complications.

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Cardiogenic Shock

Primary pump failure, SCAI staging (A–E), PAC hemodynamics (CPO, PAPi), inotrope selection, emergent revascularization, and mechanical circulatory support.

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