Proactive desmopressin for the prevention of serum sodium overcorrection in moderate-to-severe hyponatremia: a systematic review and meta-analysis.
Primary review authors, 2026 · 6 studies included
Summary
Six studies, 1,881 patients, 168 given proactive desmopressin; predominantly observational evidence.
Conclusion
Overcorrection OR 0.29 (95% CI 0.19–0.45); sparse ODS events and no demonstrated mortality benefit. Selection/confounding and variable regimens prevent a universal protocol.