Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis
Monnet X, Marik PE, Teboul JL, 2016 · 21 studies included
Summary
Meta-analysis of 21 clinical studies (n=991) evaluating passive leg raising (PLR) coupled with real-time cardiac output measurement to predict fluid responsiveness.
Conclusion
A PLR-induced increase in cardiac output >= 10% reliably predicts fluid responsiveness with a pooled sensitivity of 85% and pooled specificity of 91%, independent of ventilation mode or cardiac rhythm.
Clinical Context & Relevant Topics (2)
Disease ReferenceCellular dysoxia, DO2/VO2 physiology, the 4 shock phenotypes, dynamic fluid responsiveness (PLR/PPV) vs fluid tolerance (VExUS), and vasoactive pharmacology.
The subset of sepsis with profound circulatory and cellular/metabolic abnormality — clinically identified by a vasopressor requirement to maintain MAP ≥ 65 mmHg plus lactate > 2 mmol/L despite adequate fluid resuscitation.