Efficacy of cyproheptadine in the management of serotonin toxicity following deliberate self-poisoning: a systematic review
King E, Rotella JA, 2025 · 12 studies included
Summary
Twelve reports, mostly case reports plus one case series, used heterogeneous cyproheptadine regimens and provided insufficient outcome reporting to establish efficacy.
Conclusion
Evidence for cyproheptadine is very low certainty; supportive care, stopping serotonergic agents, sedation, active cooling and organ support remain the core of severe serotonin-toxicity management.