Daily sedation interruption versus no daily sedation interruption for critically ill adults and children requiring invasive mechanical ventilation.
Rose L et al., 2026 · 23 studies included
Summary
Twenty-three trials, 5,987 enrolled (4,910 cluster-adjusted) adults and children; comparators ranged from usual sedation to protocolized light/analgesia-first strategies.
Conclusion
DSI probably reduced mortality (RR 0.88, 95% CI 0.77–0.99; moderate certainty) and may shorten ventilation (low certainty, high heterogeneity). Delirium effects were very uncertain. Apply daily awakening with safety screening and analgesia/light-sedation goals; this pooled result does not establish superiority over every modern light-sedation protocol or justify interruption during dangerous instability.