Nutrition Interventions to Support Oral Intake in Acute and Critical Care: A Systematic Review of Randomized Controlled Trials with Meta-Analysis
Osagiede LE et al., 2026 · 16 studies included
Summary
Sixteen trials, 3,795 participants; none was conducted exclusively in an ICU. Most studies had bias concerns.
Conclusion
Interventions improved intake and showed mortality signals in acute-care populations, but heterogeneity and indirectness limit ICU applicability. Do not describe this review as demonstrating an ICU mortality benefit.