Tranexamic acid for postpartum bleeding: a systematic review and individual patient data meta-analysis of randomised controlled trials
Ker K, et al., 2024 · 5 studies included
Summary
Individual-patient-data meta-analysis of large prospectively registered placebo-controlled randomized trials assessing TXA around childbirth, including treatment and prevention settings.
Conclusion
The evidence supports prompt TXA for clinically diagnosed postpartum hemorrhage but does not justify presenting prophylactic TXA as universally beneficial before PPH is diagnosed; treatment and prevention indications must be kept distinct.