Linezolid versus clindamycin for toxin inhibition in severe skin and soft tissue infections: a systematic review and meta-analysis.
Stropes A et al., 2026 · 4 studies included
Summary
Four retrospective studies, with moderate/significant bias; comparisons included the accompanying anti-gram-positive regimen.
Conclusion
No demonstrated ICU/hospital-stay difference; limited mortality data. AKI signals may reflect regimen differences and confounding; no established mortality superiority or equivalence.