Clinical analysis of antipsychotic-induced catatonia and neuroleptic malignant syndrome: a systematic review
Systematic review of antipsychotic-induced catatonia and NMS case literature, 2023 · 144 studies included
Summary
The review included 165 antipsychotic-induced catatonia/NMS events from 144 case reports and series and found substantial clinical overlap, with events reported after both first- and second-generation antipsychotics.
Conclusion
NMS remains a clinical diagnosis supported mainly by low-level evidence; prompt withdrawal of the offending agent, aggressive supportive care and specialist-directed therapy for severe cases are central.
Clinical Context & Relevant Topics (2)
Disease ReferenceBedside differentiation and ICU management of serotonin toxicity versus neuroleptic malignant syndrome.
Safe ICU use of antipsychotics: delirium evidence, agitation control, QTc/torsades risk, NMS, EPS, interactions, and deprescribing.