Multicomponent non-pharmacological interventions for preventing delirium in critically ill patients: a systematic review and meta-analysis of randomized controlled trials.
Wang et al., 2026 · 13 studies included
Summary
13 randomized trials, 5,525 patients; lower delirium incidence RR 0.53 (95% CI 0.36–0.76), with substantial heterogeneity.
Conclusion
Low-certainty prevention signal; no demonstrated mortality/duration benefit or superior component combination. Publisher DOI corrects a mismatched identifier in retrieved metadata.
Clinical Context & Relevant Topics (2)
Disease ReferenceAntipsychotics in the ICU
Safe ICU use of antipsychotics: delirium evidence, agitation control, QTc/torsades risk, NMS, EPS, interactions, and deprescribing.
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ICU Sedation, Analgesia, Delirium & Liberation
Analgesia-first sedation, light sedation targets, ABCDEF bundle, spontaneous breathing trials, and non-pharmacologic delirium mitigation.
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