Meta-Analysis

Targeted temperature management after cardiac arrest

Arrich J, Holzer M, Havel C, et al., 2023 · 13 studies included

Summary

Cochrane systematic review and meta-analysis of 13 randomized clinical trials (n=4,249) comparing targeted hypothermia (32-34°C) with normothermia or fever prevention in adults resuscitated from cardiac arrest.

Conclusion

Targeted hypothermia (32-34°C) does not improve survival (RR 0.97, 95% CI 0.90 to 1.04) or favorable neurological outcome (RR 0.99, 95% CI 0.89 to 1.09) compared with actively maintained normothermia (36.5-37.7°C), but increases the risk of serious arrhythmias.

High certainty

Clinical Context & Relevant Topics (1)

Disease Reference

Cardiac Arrest & Post–Cardiac Arrest Care

Multimodal resuscitation, post-cardiac arrest syndrome management, targeted temperature control, and delayed neuroprognostication.

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