Potential novel role of asthma biologics as rescue therapy in the intensive care unit for life-threatening asthma exacerbations: a systematic review.
Carriera L et al., 2025 · 14 studies included
Summary
Thirteen case reports and one case series describing biologic rescue during refractory near-fatal asthma.
Conclusion
The evidence is uncontrolled and highly susceptible to selection/publication bias. Biologics are not established acute ICU rescue treatment; cases do not demonstrate efficacy, optimal timing or a standard dose. Any exceptional use needs specialist assessment.
Clinical Context & Relevant Topics (2)
Disease ReferencePathophysiology of dynamic hyperinflation, auto-PEEP hemodynamics, stepped acute pharmacotherapy, and ventilator mechanics in status asthmaticus.
Specialist-level VV/VA ECMO bedside management: selection, cannulation, gas exchange, hemodynamics, anticoagulation, circuit troubleshooting, organ support, ultrasound, ECPR, weaning and decannulation.