Early Aspirin Discontinuation Versus 12-Month Dual Antiplatelet Therapy after Percutaneous Coronary Intervention for Acute Coronary Syndrome: A Meta-Analysis of Randomized Trials.
Kolupoti et al., 2026 · 9 studies included
Summary
Nine randomized datasets/subanalyses, 31,505 selected ACS-PCI patients; aspirin stopped at 1–3 months with continued P2Y12 inhibition.
Conclusion
Less bleeding/net adverse events; ischemic confidence intervals do not prove equivalence, especially stent thrombosis. Selection, timing and accompanying P2Y12 therapy limit generalization to acute ICU decisions.